Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization (Small 10/2023)
نویسندگان
چکیده
Radiotherapy Sensitization Enhancing the cellular radiosensitivity is instrumental for improving efficacy of tumor radiotherapy. In article number 2206415, Junping Wang, Cheng and co-workers report a tumor-penetrating nanomaterial iCoDMSN constituted with dendritic mesoporous silica nanoparticles iRGD peptide-conjugated [email protected] nanodots. By decreasing KEAP1 expression upregulating nuclear factor erythroid 2-related 2 (NRF2) heme oxygenase 1 (HMOX1), expands labile iron pool in cancer cells initiates ferroptosis, whereby sensitizes to ionized radiation eliminates tumors combined
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ژورنال
عنوان ژورنال: Small
سال: 2023
ISSN: ['1613-6829', '1613-6810']
DOI: https://doi.org/10.1002/smll.202370058